论文部分内容阅读
目的探讨温州地区先天性心脏病(CHD)发病的相关影响因素,为CHD的病因学研究和制定预防措施提供科学依据。方法本研究采用1∶1病例对照研究,通过自行设计的调查问卷进行调查,采集温州地区2015 2016年围生儿中500名CHD患儿和500名正常儿童母亲的相关信息,采用单因素和多因素条件logistic回归分析进行CHD的相关因素分析。结果单因素和多因素条件logistic回归分析结果显示,大专及以上文化程度、单胎妊娠、服用叶酸等为保护因素,OR值分别为0.741(95%CI:0.551~0.996)、0.191(95%CI:0.083~0.441)和0.528(95%CI:0.368~0.757);接触化学物质、孕早期感冒、服促排卵药、接触宠物、居屋装修、染发、饮酒、异常生育史、丈夫吸烟9项为危险因素,OR值分别为9.033(95%CI:1.116~73.129)、1.616(95%CI:1.193~2.189)、17.333(95%CI:7.197~136.751)、2.679(95%CI:1.089~6.593)、15.240(95%CI:5.945~39.068)、3.030(95%CI:1.656~5.546)、8.448(95%CI:1.043~68.432)、3.028(95%CI:1.655~5.538)和1.336(95%CI:1.008~1.772)。结论积极做好预防工作,针对危险因素进行有效干预,降低CHD的发生率,提高人口素质。
Objective To investigate the related risk factors of CHD in Wenzhou and to provide a scientific basis for the etiological study of CHD and its preventive measures. Methods In this study, a 1: 1 case-control study was conducted and questionnaires were designed to collect information about 500 CHD children and 500 normal mothers in perinatal infancy in 2015 in Wenzhou area. Single-factor and multi-factor Factors conditional logistic regression analysis of CHD related factors. Results The results of univariate and multivariate conditional logistic regression analysis showed that the OR values were 0.741 (95% CI: 0.551-0.996) and 0.191 (95% CI) respectively, with college degree and above, singleton pregnancy and taking folic acid as protective factors. : 0.083 ~ 0.441), and 0.528 (95% CI: 0.368 ~ 0.757). Nine of the items that were exposed to chemicals, flu in early pregnancy, ovulation induction, pet contact, home improvement, hair coloring, drinking, abnormal birth history, The odds ratios for risk factors were 9.033 (95% CI: 1.116-73.129), 1.616 (95% CI: 1.193-2.189), 17.333 (95% CI: 7.197-136.751) and 2.679 (95% CI: 1.089-6.593) , 3.030 (95% CI: 1.656-5.546), 8.448 (95% CI: 1.043-68.432), 3.028 (95% CI: 1.655-5.538) and 1.336 : 1.008 ~ 1.772). Conclusion Active prevention work, effective intervention for risk factors to reduce the incidence of CHD and improve the quality of the population.