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核转录因子ｋａｐｐａ Ｂ（ＮＦκＢ）是一组重要的转录调节因子，可在免疫刺激剂等多种因素作用下激活而调节基因的转录，参与调节许多与免疫功能和炎症有关的基因。ＩκＢ（Ｉｎｈｉｂｉｔｏｒｙ ＮＦκＢ）是其抑制分子，对其激活的调控起着关键作用。本文综述了ＮＦκＢ激活及调控的有关机理，为对其进一步研究提供理论依据。
Nuclear factor kappa B (NF-κB) is a group of important transcriptional regulators that regulate the transcription of genes under the action of immune stimulators and many other factors and are involved in the regulation of many genes involved in immune function and inflammation. IκB (Inhibitory NF κB) is its inhibitory molecules, the activation of its regulation plays a key role. This review summarizes the relevant mechanisms of NF-κB activation and regulation, providing a theoretical basis for its further study.