调节性T细胞是机体维持自身耐受的重要组成部分。CD4+CD25+T细胞以持续高表达CD25为特征,可通过细胞间直接接触或分泌TGF-β、IL-10来发挥抑制功能。它广泛参与自身免疫耐受、肿瘤免疫、移植免疫。现就其发育、特性、发挥功能的机制以及在移植免疫耐受中的作用和应用前景作一综述。 Regulatory T cells are an important part of the body to maintain its own tolerance. CD4 + CD25 + T cells are characterized by persistent high expression of CD25 and can exert their inhibitory function through direct contact or secretion of TGF-β and IL-10 between cells. It is widely involved in autoimmune tolerance, tumor immunity, transplant immunity. Now on its development, characteristics, mechanisms of functioning and immune tolerance in transplantation in the role and application prospects are reviewed.