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GR43175,3-[2-(二甲胺)乙基]-N-甲基-IH-吲哚-5-甲烷-磺胺,是一种5-HT_1样受体激动剂,对动物的颈动脉血管床的动静脉吻合口有短时的选择性血管收缩作用。偏头痛的发病机理可能与颈动脉循环的动静脉吻合口有关,作者首次将该药应用于急性偏头痛患者。
GR43175 3- [2- (Dimethylamino) ethyl] -N-methyl-1H-indole-5-methanesulfonamide is a 5-HT1-like receptor agonist that acts on the carotid artery Bed anastomotic arteriovenous short-term selective vasoconstriction. The pathogenesis of migraine may be related to arteriovenous anastomotic carotid circulation, the author for the first time the drug applied to patients with acute migraine.