论文部分内容阅读
目的探讨多索茶碱治疗慢性阻塞性肺疾病的临床疗效。方法选取2013年12月—2014年12月在北京市仁和医院接受治疗的88例慢性阻塞性肺疾病患者,随机分为观察组和对照组,每组44例。对照组患者在常规治疗基础上采用氨茶碱治疗,观察组患者在常规治疗基础上采用多索茶碱治疗,比较两组患者的肺功能〔第1秒用力呼气容积/用力肺活量(FEV1/FVC)〕和血气分析指标〔二氧化碳分压(Pa CO2)、血氧分压(Pa O2)〕、临床疗效及不良反应发生情况。结果治疗后观察组FEV1/FVC、Pa O2高于对照组,Pa CO2低于对照组,总有效率高于对照组,不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论慢性阻塞性肺疾病患者采用多索茶碱治疗,可以有效提高临床疗效,明显改善患者的血气分析指标与肺功能,同时不良反应发生率较小。
Objective To investigate the clinical efficacy of doxofylline in the treatment of chronic obstructive pulmonary disease. Methods Eighty-eight chronic obstructive pulmonary disease patients treated in Renhe Hospital of Beijing between December 2013 and December 2014 were randomly divided into observation group and control group, 44 cases in each group. The patients in the control group were treated with aminophylline on the basis of routine treatment. The patients in the observation group were treated with doxofylline on the basis of routine treatment. The pulmonary function (FEV1 / FVC)] and blood gas analysis indicators (partial pressure of carbon dioxide (PaCO2), partial pressure of oxygen (PaO2)], clinical efficacy and adverse reactions. Results After treatment, FEV1 / FVC and Pa O2 in the observation group were higher than those in the control group, PaCO2 was lower than that in the control group, the total effective rate was higher than that in the control group, and the incidence of adverse reactions was lower than that in the control group (P <0.05) . Conclusion Doxofylline treatment in patients with chronic obstructive pulmonary disease can effectively improve the clinical efficacy, significantly improve the patient’s blood gas analysis indicators and lung function, while the incidence of adverse reactions is small.