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对60例患者的胃标本进行了银染色和免疫组化染色，探讨细胞核仁形成区相关嗜银蛋白（AgNOR）和增殖细胞核抗原（PCNA）在胃癌及不典型增生中的表达。结果表明：胃癌组AgNOR和PCNA的表达明显高于不典型增生组和慢性浅表性胃炎组，而不典型增生组高于慢性浅表性胃炎组，差异均有显著性意义（P＜0．05）。结果提示，AgNOR和PCNA的表达异常，可用于临床判断良性病变与恶性病变的指标之一。
Silver staining and immunohistochemical staining were performed on gastric specimens from 60 patients to investigate the expression of AgNOR and PCNA in the nucleolus formation region of gastric cancer and atypical hyperplasia. The results showed that the expression of AgNOR and PCNA in gastric cancer group was significantly higher than that in atypical hyperplasia group and chronic superficial gastritis group, and that in atypical hyperplasia group was higher than that in chronic superficial gastritis group (P<0. 05). The results suggest that the abnormal expression of AgNOR and PCNA can be used as one of the indicators of clinical judgment of benign lesions and malignant lesions.