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1969年首先发现金属络合物顺式二氯二氨合铂 (简称顺铂 )具有抗肿瘤活性。现已合成了几千种铂络合物 ,其中 1 0 %具有抗肿瘤活性 ,有一些铂络合物已进入临床应用或临床试验。铂络合物产生细胞毒性和抗肿瘤活性的原因 ,是由于其与肿瘤细胞的ＤＮＡ结合。结合方式有三种 :与ＤＮ
First discovered in 1969 metal complex cis-dichloro-dichloro platinum (referred to as cisplatin) has anti-tumor activity. Thousands of platinum complexes have been synthesized, of which 10% have anti-tumor activity and some platinum complexes have entered clinical use or clinical trials. The reasons for the cytotoxic and antitumor activity of platinum complexes are due to their binding to the DNA of tumor cells. There are three ways to combine: with DN