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目的 :通过观察解酒护肝饮对酒精性肝损伤大鼠血清和肝组织 IL- 8的影响 ,验证其对酒精性肝损伤的防治作用及药效。方法 :以益肝灵、葛花解酲汤为对照 ,采用白酒灌胃造模 ,分别预防给药和治疗给药后检测各组大鼠血清和肝组织 IL- 8含量。结果 :预防给药结果表明 ,模型大鼠血清及肝组织 IL- 8较正常组明显升高 ,均具有显著性差异 (P<0 .0 1 ) ;预防给药各组血清及肝组织 IL- 8低于模型组 ,均具有显著性差异 (P<0 .0 1或 <0 .0 5) ,但各治疗组间未见明显统计学差异 (P>0 .0 5)。治疗给药结果与预防给药结果一致。结论 :解酒护肝饮能够通过降低血清和肝内 IL- 8含量 ,防治酒精性肝损伤。
Objective : To observe the effect of Jiejiu Gangan Decoction on serum and liver IL-8 in rats with alcoholic liver injury, and to verify its preventive and therapeutic effects on alcoholic liver injury. Methods : Yiganling and Gehua Jieyu Decoction were used as control, white spirits were used to establish the stomach model, respectively, and the content of IL-8 in serum and liver tissue of each group was detected after administration and treatment respectively. Results: The result of preventive administration showed that serum and hepatic IL-8 levels in the model rats were significantly higher than those in the normal group (P<0.01); IL-1 in serum and liver tissue in each group was prevented. 8 Compared with the model group, there was a significant difference (P<0.01 or <0.05), but there was no significant difference between the treatment groups (P>0.05). The results of the therapeutic administration were consistent with the results of the prophylactic administration. Conclusion: Jiejiu Gangan Decoction can prevent and treat alcoholic liver injury by reducing serum and intrahepatic IL-8 levels.