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目的研究选择性门静脉栓塞的作用及安全性。方法用α—氰基丙烯酸正辛酯选择性栓塞SD大鼠的门静脉左支 ,分别于术后1、3、7、14、30d处死 ,与正常大鼠比较 ,进行大体、组织学及增殖细胞核抗原染色观察 ,并检测血常规和肝功能。结果被栓塞肝叶大片坏死、纤维化、萎缩 ,术后30d由栓塞前占全肝重70 %降至8 % (P<0.01)。未栓塞肝叶代偿性肥大 ,术后30d重量达术前的3倍 ,门静脉分支扩张 ,肝细胞增生活跃 ,增殖细胞核抗原标记指数术后第1d升至术前水平的4.3倍 (P<0.01) ,术后30d降至术前水平。血常规无明显变化 ,肝功能呈一过性改变 ,主要为转氨酶升高 ,2周内恢复正常。结论选择性门静脉栓塞可使被栓塞肝叶明显萎缩而未栓塞肝叶代偿性增生肥大 ,效果安全可靠 ,为进一步用于临床肝癌治疗提供了实验依据。
Objective To study the effect and safety of selective portal vein embolization. Methods Selective embolization of the left portal vein of SD rats with n-octyl α-cyanoacrylate was performed at 1, 3, 7, 14 and 30 days after operation. Compared with normal rats, gross, histological and proliferating cell nuclei Antigen stain was observed, and blood and liver function tests. Results The hepatic lobules were necrosis, fibrosis and atrophy after embolization. The total hepatic weight decreased from 70% to 8% (P <0.01) 30 days after embolization. Without embolized hepatic lobe compensatory hypertrophy, 30 days after operation, the weight of the portal vein was three times of that before operation. The branches of the portal vein were dilated and the hepatocyte hyperplasia was active. The index of proliferating cell nuclear antigen labeling rose to 4.3 times of preoperative level on the first day after operation (P <0.01) ), 30d after surgery reduced to the preoperative level. No significant changes in blood, liver function was a transient change, mainly elevated aminotransferases, returned to normal within 2 weeks. Conclusions Selective portal vein embolization can significantly atrophy of the embolized liver lobe without compensatory enlargement and hypertrophy of the embolized lobe, which is safe and reliable, which provides an experimental basis for further clinical treatment of liver cancer.