载脂蛋白A-I是血浆中高密度脂蛋白的主要蛋白成份,十多年来其基因结构已清楚,并在染色体上得以定位。目前ApoA-I基因在原核、真核细胞以及转基因鼠中均已获表达,对于该基因的调控机理正在深入研究。本文就以上几方面的进展加以综述。 Apolipoprotein A-I is a major protein component of high-density lipoproteins in plasma, and its genetic structure has been clearly identified for more than a decade and mapped on chromosomes. Currently ApoA-I gene in prokaryotic, eukaryotic cells and transgenic mice have been expressed, the regulation of the gene’s mechanism is being studied in depth. This article summarizes the progress in the above aspects.