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目的观察比索洛尔联合培哚普利治疗高原地区慢性充血性心力衰竭(chronic heart failure,CHF)的治疗效果。方法 90例高原地区CHF患者随机分为A组43例,B组47例。A组在常规治疗基础上给予培哚普利,B组在A组治疗基础上,给予比索洛尔治疗,2组疗程均为1a。比较2组疗效及治疗前、后心率、血压、左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)、左心室收缩末期内径(left ventricular end-systolic diameter,LVSED)、左心室射血分数(left ventricular ejection fraction,LVEF)、每分输出量(cardiac output,CO)、每搏输出量(strokevolume,SV)、二尖瓣舒张早期心室充盈速度最大值(A峰)/舒张晚期心室充盈速度最大值(E峰)(A/E比值)、短轴缩短率(left ventricular fraction shortening,FS)。结果 A组总有效率73.0%,B组总有效率86.5%,2组比较差异有统计学意义(P<0.05);2组治疗后血压、心率、A/E比值均较治疗前下降(P<0.05),LVEDD,LVSED均较治疗前缩小(P<0.05),CO,SV,LVEF,FS均较治疗前上升(P<0.05);B组治疗后A/E比值,LVEF,LVEDD,LVSED与A组比较差异有统计学意义(P<0.05)。结论培哚普利联合比索洛尔可改善高原地区CHF患者的心功能。
Objective To observe the therapeutic effect of bisoprolol combined with perindopril in the treatment of chronic heart failure (CHF) in the plateau. Methods Ninety-nine patients with CHF in the plateau were randomly divided into group A (n = 43) and group B (n = 47). Group A was given perindopril on the basis of routine treatment. Group B was treated with bisoprolol on the basis of group A, and the two courses of treatment were all la. The changes of heart rate, blood pressure, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVSED), left ventricular ejection fraction left ventricular ejection fraction (LVEF), cardiac output (CO), stroke volume (SV), peak mitral early ventricular filling velocity (A peak) / late diastolic ventricular filling velocity Maximum (E peak) (A / E ratio), short axis shortening (left ventricular fractional shortening, FS). Results The total effective rate in group A was 73.0%, and the total effective rate in group B was 86.5% (P <0.05). The blood pressure, heart rate and A / E ratio of two groups were significantly lower than those before treatment (P (P <0.05). The LVEDD and LVSED in both groups were decreased (P <0.05) and the levels of CO, SV, LVEF and FS were higher than those before treatment (P <0.05). The A / E ratio, LVEF, LVEDD, LVSED Compared with group A, the difference was statistically significant (P <0.05). Conclusion Perindopril combined with bisoprolol can improve cardiac function in patients with CHF in the high altitude area.