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目的了解GSTM1、GSTT1基因多态性在新疆肺结核患者中的分布。方法采用多重聚合酶链式反应(PCR)检测1 675例肺结核患者的GSTM1、GSTT1的基因型。结果 GSTM1、GSTT1纯合缺失基因型的频率分别为53.91%、29.25%;GSTM1/GSTT1联合基因型GSTM1(-)/GSTT1(-)、GSTM1(-)/GSTT1(+)、GSTM1(+)/GSTT1(-)和GSTM1(+)/GSTT1(+)的分布频率分别为16.72%、37.19%、12.54%和33.55%。结论肺结核患者的GSTM1、GSTT1基因不受年龄、性别、吸烟、饮酒的影响,但具有种族、地区差异性。
Objective To investigate the distribution of GSTM1 and GSTT1 gene polymorphisms in patients with pulmonary tuberculosis in Xinjiang. Methods The genotypes of GSTM1 and GSTT1 in 1 675 pulmonary tuberculosis patients were detected by multiplex polymerase chain reaction (PCR). Results The frequencies of GSTM1 / GSTT1 homozygous deletion genotypes were 53.91% and 29.25%, respectively. The frequencies of GSTM1 / GSTT1 and GSTM1 / GSTT1 / GSTM1 / GSTT1 + / GSTT1 / The distribution frequencies of GSTT1 (-) and GSTM1 (+) / GSTT1 (+) were 16.72%, 37.19%, 12.54% and 33.55%, respectively. Conclusions GSTM1 and GSTT1 genes in patients with tuberculosis are not affected by age, sex, smoking, alcohol consumption, but with ethnic and regional differences.