青蒿素是我国70年代初发现的新结构类型的抗疟药。具有杀虫退热快,临床不良反应少,与其他抗疟药无明显交叉耐药性等优点,受到国内、外高度重视。但由于青蒿素本身在水和油中的溶解度都很低,所需剂量大,使用不便,于是其水溶性衍生物青蒿酯钠和油溶性衍生物蒿甲醚便应运而生。80年代初中国青蒿素及其衍生物开发研究指导委 Artemisinin is a new type of antimalarial drug discovered in early 1970s in our country. With insecticidal antipyretics fast, less adverse clinical reactions, and no significant cross-resistance with other anti-malarial drugs, etc., by domestic and foreign attaches great importance. However, since artemisinin itself has a low solubility in water and oil, it requires a large dosage and inconvenient use. Therefore, artemisinin, its water-soluble derivative, and artemether, an oil-soluble derivative, came into being. Early 80s China artemisinin and its derivatives development and research guide