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最近人体试验发现,伏隔核(NAc)在神经病理性疼痛慢性化中发挥重要作用,但是具体机制不清楚。本研究采用慢性痛动物模型,探索NAc参与神经病理性疼痛慢性化的机制。方法:(1)动物模型:大鼠坐骨神经分支部分损伤(SNI)模型;(2)检测时间点:SNI术前2 d、术后5 d和术后28 d;(3)评价指标:触诱发痛、静息状态功能磁共振成像(rs-f MRI)功能连接、NAc受体基因表达(DR1a、DR2、KOR、CB1、
Recent human trials found that nucleus accumbens (NAc) play an important role in the chronic neuropathic pain, but the exact mechanism is unclear. In this study, chronic pain model was used to explore the mechanism of NAc involvement in chronic neuropathic pain. Methods: (1) Animal models: Partial sciatic nerve branch injury (SNI) model in rats; (2) Time points of detection: 2 days before SNI, 5 days after surgery and 28 days after surgery; (3) Pain, resting state functional magnetic resonance imaging (rs-f MRI) functional connections, NAc receptor gene expression (DR1a, DR2, KOR, CB1,