论文部分内容阅读
There are three types of fat tissue in mammals:white fat tissue (WAT),classic brown fat tissue (cBAT),and inducible brown fat tissue (iBAT) or beige fat tissue.The brown fat tissue in the human body is more similar to the induced brown fat tissue in mice.The main function of WAT is to store energy in the form of triacylglycerols and to regulate endocrine function.The main function of cBAT and iBAT is to generate heat and maintain the energy balance of the body.A cold environment and exercise can stimulate the browning of white fat tissue.The browning of white fat tissue is a complex process involving many factors,with PRDM16,PPARγ and PGC-1α being the core transcription factors related to the process.Previous studies showed that white adipose browning is beneficial for the treatment of obesity,diabetes,fatty liver and other diseases.On the other hand,it can promote the progression of malignant tumors.Under normal conditions,the different types of fat tissue maintain a dynamic balance in the human body.Therefore,obtaining a better understanding of this balance and determining how to intervene at the early stages of metabolic imbalance are necessary.