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分子内Wittig反应是合成炔烃的有用方法,以R基烷酰基亚甲基三苯基膦在加热的条件下脱掉一分子三苯氧膦,得到相应的炔类化合物。然而,此反应仅局限于当R是酯基、氰基或苯基。当R是H或烷基时,则不能获得炔烃。在我们研究的同时,Comasseto等人亦研究了分子内Wittig反应用于炔烃的合成,发现当R是烷硫基、苯硫基以及苯硒基时,该反应亦能顺利地进行,获得炔烃。 我们发现了当R等于膦酸酯基时,分子内Wittig反应亦能顺利地进行,获得较好产率
The intramolecular Wittig reaction is a useful method for the synthesis of alkynes, with R-alkanoylmethylenetriphenylphosphine off one molecule of trophylphosphine under heating to give the corresponding acetylenic compound. However, this reaction is limited to when R is an ester group, a cyano group or a phenyl group. When R is H or alkyl, no alkyne can be obtained. At the same time as our study, Comasseto et al. Also studied the intramolecular Wittig reaction for the synthesis of alkynes and found that when R is alkylthio, phenylthio and phenylseleno, the reaction proceeds smoothly to obtain the alkyne hydrocarbon. We have found that when R is equal to the phosphonate group, the intramolecular Wittig reaction proceeds smoothly, resulting in a better yield