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目的探讨全身麻醉联合胸段硬膜外阻滞麻醉下行胸腹腔镜微创手术治疗食管癌对患者肿瘤相关因子的影响。方法将206例食管癌患者随机分为试验组和对照组各103例。试验组经全身麻醉联合胸腹硬膜外麻醉后给予胸腹腔镜微创手术治疗,对照组经全身麻醉后给予胸腹腔镜微创手术治疗,对比观察2组患者临床治疗前后肿瘤相关血清标志物水平变化。结果治疗前2组患者血清癌胚抗原(CEA)、血清糖类抗原125(CA125)、血清糖类抗原19-9(CA19-9)水平比较差异均无统计学意义(P>0.05)。治疗后2组患者上述肿瘤血清标志物水平均降低,且试验组患者降低幅度明显大于对照组,差异均具有统计学意义(P<0.05)。结论全身麻醉联合胸段硬膜外阻滞麻醉下行胸腹腔镜微创手术治疗食管癌可显著降低患者血清CEA、CA125、CA19-9等肿瘤相关因子水平。
Objective To investigate the effect of general anesthesia combined with thoracic epidural anesthesia on thoraco-laparoscopic minimally invasive surgery in patients with esophageal cancer on tumor-related factors. Methods 206 patients with esophageal cancer were randomly divided into experimental group and control group of 103 cases. The experimental group was given thoracic and laparoscopic minimally invasive surgery after general anesthesia combined with thoracoabdominal epidural anesthesia. The control group was given thoracoscopic laparoscopic minimally invasive surgery after general anesthesia. The changes of tumor-associated serum markers Horizontal changes. Results There was no significant difference in serum carcinoembryonic antigen (CEA), serum carbohydrate antigen125 (CA125) and serum carbohydrate antigen 19-9 (CA19-9) between the two groups before treatment (P> 0.05). After treatment, the level of serum tumor markers in the two groups of patients were decreased, and the reduction rate in the experimental group was significantly greater than that in the control group, the difference was statistically significant (P <0.05). Conclusion Thoraco-laparoscopic minimally invasive surgery under general anesthesia combined with thoracic epidural anesthesia for the treatment of esophageal cancer can significantly reduce the serum levels of CEA, CA125, CA19-9 and other tumor-related factors.