雄性ＳＤ大鼠每周经口给予２ｍｇ／ｋｇ黄磷连续５周；每周经口给予１２００ｍｇ／ｋｇ四氯化碳连续４周。染磷组肝细胞微粒体酶系各指标部分升高，部分降低，部分则改变较小。染四氯化碳组微粒体酶系所有指标均明显下降，细胞损伤也较黄磷染毒为重。结果提示在肝细胞毒性中，反映出四氯化碳、黄磷两种毒物在趋肝毒作用和机制方面存在不同。 Male SD rats were orally administered with 2 mg / kg of yellow phosphorus per week for 5 consecutive weeks; 1200 mg / kg of carbon tetrachloride was administered orally weekly for 4 weeks. In phosphorus-contaminated group, the indexes of hepatocyte microsomes increased, partly decreased and partly changed little. Dyeing carbon tetrachloride group microsomes enzyme all indicators were significantly decreased cell damage than yellow phosphorus-based. The results suggest that in the cytotoxicity of hepatocytes, it is reflected that there are differences in hepatotoxicity and mechanism between the two toxicants of carbon tetrachloride and yellow phosphorus.