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目的了解广西肝癌高发区健康人群血清微囊藻毒素-LR(microcystin-LR,MC-LR)水平及其影响因素。方法于2015年6月,收集广西肝癌高发区健康人群103人、低发区健康人群100人的基本信息及静脉血,采用酶联免疫法检测血清MC-LR水平以及乙肝病毒表面抗原(HBs Ag),分析两组人群血清MC-LR水平及其相关影响因素。结果广西肝癌高发区健康人群血清MC-LR水平(0.088±0.040μg/L)高于低发区(0.028±0.013μg/L),差异有统计学意义(P<0.01);无论是肝癌高发区还是低发区,HBs Ag阳性人群与阴性人群血清MC-LR水平差异无统计学意义(P>0.05)。多重逐步线性回归分析结果显示,有塘边渗井水或沟塘水饮用史及本地鱼、鸭食用频率较高者血清中MC-LR水平较高。结论塘边渗井水或沟塘水饮用史及本地鱼、鸭食用频率高是广西肝癌高发区健康人群血清MC-LR水平升高的影响因素。
Objective To investigate the level of microcystin-LR (MC-LR) and its influencing factors in healthy population of high incidence of HCC in Guangxi. Methods In June 2015, the basic information and venous blood samples of 103 healthy subjects and 100 healthy subjects from low-risk areas of Guangxi were collected. The level of serum MC-LR and the level of hepatitis B virus surface antigen (HBsAg ), The level of serum MC-LR in two groups and its related factors were analyzed. Results The level of serum MC-LR in healthy population of high incidence of HCC in Guangxi (0.088 ± 0.040μg / L) was higher than that in the low incidence (0.028 ± 0.013μg / L), the difference was statistically significant (P <0.01) There was no significant difference in serum MC-LR level between HBsAg positive and negative groups (P> 0.05). Multiple stepwise linear regression analysis showed that there was a high MC-LR level in the sera with the history of drinking water in the pond or the drinking water of the ditches and the higher frequency of consumption by the local fish and ducks. Conclusions The drinking water in the pond or the drinking water of the ditches and the high consumption of local fish and ducks in the ponds are the influencing factors of the elevation of serum MC-LR level in healthy population of high incidence of HCC in Guangxi.