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目的:了解南京市妇幼保健院药品不良反应(ADR)发生的特点及一般规律,促进临床合理用药。方法:采用回顾性研究方法,对南京市妇幼保健院2008～2010年收集的138例ADR报告分别从患者性别、年龄、给药途径、药品种类、累及器官或系统、临床表现等方面进行统计、分析。结果:138例ADR中,抗感染药占60.87%,妇科用药占21.01%。静脉给药引发的ADR例数最多,以皮肤及其附件损害最多。结论:临床应合理使用抗感染药物,加强对中药制剂的质量检测和使用规范,以减少或避免ADR的发生。
Objective: To understand the characteristics and general rules of adverse drug reaction (ADR) in Nanjing MCH hospital and to promote rational drug use in clinic. Methods: A retrospective study was conducted to analyze the 138 ADRs collected by Nanjing MCH from 2008 to 2010, respectively, from the aspects of patient’s sex, age, route of administration, type of drug, organ or system involved, clinical manifestation and so on. analysis. Results: 138 cases of ADR, anti-infective drugs accounted for 60.87%, gynecological medication accounted for 21.01%. The highest number of ADRs caused by intravenous administration, most damage to the skin and its annexes. Conclusion: The clinical should be reasonable use of anti-infective drugs, to strengthen the quality control of traditional Chinese medicine preparation and use of norms to reduce or avoid the occurrence of ADR.