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目的探讨单用糖皮质激素气雾剂治疗季节性变应性鼻炎的临床疗效,旨在减少药物不良反应的发生。方法选择季节性变应性鼻炎224例,随机分两组各112例,实验组应用肾上腺皮质激素鼻喷雾剂于每晨各喷两侧鼻腔一次;对照组应用氯雷他定+肾上腺皮质激素气雾剂喷鼻一次。连续应用15~20 d左右。结果根据症状及体征记分法评定疗效,试验组患者总有效率为92.86%,对照组总有效率为93.75%,有效率两组比较无显著性差异(P>0.05)。试验组患者用药后观察不良反应发生率16.07%,对照组不良反应发生率为26.79%,不良反应发生率两组比较有显著性差异(P<0.01)。结论单纯鼻腔局部应用皮质激素鼻喷雾剂,可以有效的控制季节性变应性鼻炎的临床症状,明显减少联合用药带来的不良反应。
Objective To investigate the clinical efficacy of single glucocorticoid aerosol in the treatment of seasonal allergic rhinitis, aiming to reduce the incidence of adverse drug reactions. Methods 224 cases of seasonal allergic rhinitis were randomly divided into two groups of 112 cases. The experimental group was treated with adrenal cortical hormone nasal spray on each side of the morning spray nasal cavity once; the control group loratadine + adrenocorticotropic hormone gas Spray nasal spray once. Continuous application of about 15 ~ 20 d. Results According to the symptoms and signs scoring method, the total effective rate was 92.86% in the test group and 93.75% in the control group. There was no significant difference between the two groups (P> 0.05). The incidence of adverse reactions was 16.07% in the test group and 26.79% in the control group. The incidence of adverse reactions was significantly different between the two groups (P <0.01). CONCLUSIONS: Nasal local corticosteroid nasal spray can effectively control the clinical symptoms of seasonal allergic rhinitis and significantly reduce the adverse reaction caused by combination therapy.