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临床及动物实验中,动脉移植失败的原因之一是移植物血流面不能形成一层细胞内衬,这样纤维蛋白在移植物内面形成前就会产生血凝块,特别是在移植后的前12个月。有人曾在犬动脉移植时,将上皮细胞种植到 Da-cron 血管内,使管腔内早期产生融合的细胞内衬,实验获得成功,但仅能从大动、静脉获取血管内皮,故仍缺乏来源。作者过去曾研究过腹膜的间皮细胞与上皮细胞的发育密切相关,在体外模型中,腹膜间皮细胞对动脉
One of the causes of arterial graft failure in clinical and animal experiments is that the graft blood flow surface can not form a layer of cell lining, so that fibrin produces a blood clot prior to the formation of the graft surface, especially before 12 months. It has been successfully transplanted into the Da-cron vessel during implantation into the canine artery, leading to the early generation of a fused cell lining in the lumen. Although the experiment was successful but the vascular endothelium was only obtained from the great artery and vein, it was still lacking source. In the past, the authors have examined the relationship between peritoneal mesothelial cells and the development of epithelial cells. In an in vitro model, the effects of peritoneal mesothelial cells on arterial