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目的分析中成药制剂临床应用不良反应发生的影响因素。方法选取2013年3月—2015年7月接受中成药制剂治疗发生不良反应的患者131例,收集统计使用中成药制剂治疗时发生的各种临床不良反应,对不同年龄、不同用药方法及不同药物引起的不良反应进行比较。计数资料比较采用χ~2检验。P<0.05为差异有统计学意义。结果 10岁以下的患者中成药制剂不良反应发生率(36.64%)高于其他年龄段(25.95%、16.79%、12.98%、7.64%)(均P<0.05)。口服中成药制剂不良反应发生率(50.38%)高于其他方法(31.80%、18.32%)(均P<0.05)。双黄连不良反应发生率(51.91%)高于清开灵及喜炎平(29.01%、19.08%)(均P<0.05)。结论中成药制剂临床不良反应发生与患者年龄、服药方法及药物有关。
Objective To analyze the influencing factors of clinical application adverse reactions of proprietary Chinese medicines. Methods A total of 131 patients with adverse reactions who received proprietary Chinese medicine (TCM) preparation from March 2013 to July 2015 were selected and collected. Statistical data were collected for various clinical adverse reactions during the treatment with proprietary Chinese medicines. The data of different age groups, different medication methods and different drugs Caused by adverse reactions were compared. Counting data using χ ~ 2 test. P <0.05 for the difference was statistically significant. Results The incidence of adverse reactions (36.64%) of proprietary Chinese medicines in patients under 10 years old was higher than that of other age groups (25.95%, 16.79%, 12.98%, 7.64%) (all P <0.05). The incidence of adverse reactions of oral proprietary Chinese medicines (50.38%) was higher than other methods (31.80%, 18.32%) (all P <0.05). Shuanghuanglian adverse reactions (51.91%) was higher than Qingkailing and Xiyanping (29.01%, 19.08%) (all P <0.05). Conclusion The clinical adverse reactions of Chinese medicine preparations are related to patient’s age, medication method and medicine.