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目的探索广东省早发性脑卒中患者发病的危险因素。方法从广东省7个城市18所医院住院病人中收集早发性(≤45岁)脑卒中病人371名(Ⅰ组);选取相同数量的老年脑卒中病人(>60岁)作为老年对照组(Ⅱ组);并按1∶1配对方法选取青年对照组人群(Ⅲ组)进行病例对照研究。结果单因素分析结果表明,早发性脑卒中发病的危险因素是BMI>24、高血压史、病前血压波动、高脂血症史、高血压家族史、吸烟、饮酒等因素,而高血压家族史和病前血压波动史进入多因素条件Logistic回归模型(OR值分别为3.704和13.511)。结论早发性脑卒中的防治需采取综合干预措施,重点是控制血压及改变不良的生活方式和饮食习惯,保持良好的精神心理状态。
Objective To explore the risk factors of early stroke in Guangdong Province. Methods A total of 371 stroke patients (≤45 years old) were enrolled from 18 inpatients in 7 cities of Guangdong Province (group Ⅰ). The same number of senile stroke patients (> 60 years) as the control group Group Ⅱ). The patients in the control group (group Ⅲ) were selected according to the method of 1: 1 pairing for case control study. Results The results of univariate analysis showed that the risk factors for the incidence of early-onset stroke were BMI> 24, history of hypertension, fluctuation of premorbid blood pressure, history of hyperlipidemia, family history of hypertension, smoking, drinking and other factors. Hypertension Family history and premorbid blood pressure fluctuations history into multivariate conditional Logistic regression model (OR values were 3.704 and 13.511 respectively). Conclusion Prevention and treatment of early-onset stroke need to take comprehensive interventions, with emphasis on controlling blood pressure and changing unhealthy lifestyles and eating habits, maintaining a good mental state.