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目的 :探讨表皮生长因子受体 (EGFR)在膀胱移行细胞癌 (BTCC)中表达的意义。方法 :应用免疫组织化学ABC法 ,对 3 3例BTCC及 12例正常膀胱组织中EGFR抗原进行检测。结果 :EGFR在正常膀胱移行细胞中呈阴性表达 ,在BTCC组中呈阳性表达 ,且中 /强阳性表达率与不同病理分级、临床分期、单发与多发、复发与初发间均有显著性差异(P <0 0 5 )。结论 :EGFR的过表达与BTCC生物学行为密切相关 ,在BTCC发生发展过程中起重要作用
Objective: To investigate the significance of epidermal growth factor receptor (EGFR) expression in bladder transitional cell carcinoma (BTCC). Methods: Immunohistochemical ABC method was used to detect EGFR antigen in 33 cases of BTCC and 12 cases of normal bladder tissue. Results: EGFR was negatively expressed in normal bladder transitional cell and positive in BTCC group, and there was significant difference between moderate and strong positive expression rate and different pathological grade, clinical stage, single and multiple recurrence and initial onset Difference (P <0 05). Conclusion: The overexpression of EGFR is closely related to the biological behavior of BTCC and plays an important role in the occurrence and development of BTCC