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目的:探讨高血压和炎症的关系以及评价奥美沙坦在有效降压的同时是否具有抗炎作用。方法:轻、中度高血压患者60例及健康体检者60例,用ELISA方法测定血清超敏C反应蛋白、sCD40L的水平。高血压组患者给予奥美沙坦20～40mg/d,服药8周后重复测定以上所有指标。结果:轻、中度高血压患者血清超敏C反应蛋白、sCD40L水平明显高于对照组,差异有统计学意义(P<0.05)。高血压组用药后超敏C反应蛋白、sCD40L明显下降。结论:高血压是一种慢性血管炎症性疾病,奥美沙坦在有效降压的同时具有抗炎作用。
Objective: To investigate the relationship between hypertension and inflammation and to evaluate whether olmesartan has an anti-inflammatory effect while effectively lowering blood pressure. Methods: Sixty patients with mild to moderate hypertension and 60 healthy subjects were enrolled in this study. Serum high sensitivity C-reactive protein and sCD40L levels were measured by ELISA. Hypertensive patients were given olmesartan 20 ~ 40mg / d, 8 weeks after taking the drug repeatedly measured all the above indicators. Results: The levels of serum high-sensitivity C-reactive protein and sCD40L in patients with mild to moderate hypertension were significantly higher than those in the control group (P <0.05). Hypertensive group after treatment with high-sensitivity C-reactive protein, sCD40L decreased significantly. Conclusion: Hypertension is a chronic vascular inflammatory disease. Olmesartan has an anti-inflammatory effect while effectively lowering blood pressure.