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目的 探讨开颅夹闭治疗颅内前循环破裂动脉瘤的效果.方法 采用随机平行对照法将107例颅内前循环破裂动脉瘤患者进行分组,对照组53例给予血管内介入治疗,观察组54例给予开颅夹闭治疗.观察并比较两组患者治疗后的格拉斯哥(GOS)评分及术后不良事件、复发率.结果 观察组术后总有效率(90.74%)高于对照(84.91%),差异未见统计学意义(P>0.05);观察组并发症发生率(18.52%)高于对照组(16.98%),差异未见统计学意义(P>0.05);观察组术后复发率(3.70%)低于对照组(20.75%),差异有统计学意义(P0.05);the incidence rate of complication in observation group was 18.52%, which was higher than that of control group (16.98%, P>0.05);the recurrence rate of observation group was 3.70%, which was lower than that of control group (20.75%, P<0.05).Conclusion Both methods can effectively improve the prognosis of patients, surgical clipping has big trauma, low postoperative recurrence rate, the endovascular has little trauma, more easily accepted by patients, in clinical application, should according to the specific circumstances of patients, strictly grasp the indications, select the most appropriate way of operation.