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目的:观察美托洛尔缓释片治疗扩张型心肌病的治疗效果。方法:扩张型心肌病充血性心力衰竭患者48例随机分为对照组(24例)和治疗组(24例)。对照组给予强心、利尿、血管紧张素转换酶抑制剂等常规治疗,治疗组在常规治疗基础上给予美托洛尔缓释片,首次剂量11.875 mg/d,1次/d后根据病情及个体差异,逐步加大至靶剂量或最大耐受剂量95 mg/d后坚持长期服用。2组疗程均为28周。比较2组疗效,治疗前、后心率、血压、左心室舒张末内径和左心室射血分数。结果:治疗组疗效优于对照组(P<0.05);2组治疗后血压、心率、左心室舒张末内径均较治疗前下降(P<0.05),治疗组下降优于对照组(P<0.05);2组治疗后左室射血分数均较治疗前增高(P<0.05),治疗组增高优于对照组(P<0.05)。结论:美托洛尔缓释片可改善扩张型心肌病充血性心力衰竭患者心肌功能。
Objective: To observe the effect of metoprolol sustained-release tablets in the treatment of dilated cardiomyopathy. Methods: Forty-eight patients with dilated cardiomyopathy congestive heart failure were randomly divided into control group (24 cases) and treatment group (24 cases). Patients in the control group were given conventional therapy such as cardiotomy, diuretic and angiotensin-converting enzyme inhibitors. The patients in the treatment group were given metoprolol extended-release tablets on the basis of conventional treatment. The first dose was 11.875 mg / d, once / d, Individual differences, gradually increased to the target dose or maximum tolerated dose of 95 mg / d adhere to long-term use. The two courses of treatment were 28 weeks. The effects of two groups were compared before and after treatment, heart rate, blood pressure, left ventricular end-diastolic diameter and left ventricular ejection fraction. Results: The curative effect in the treatment group was better than that in the control group (P <0.05). The blood pressure, heart rate and left ventricular end-diastolic diameter decreased after treatment in both groups (P <0.05) ). The left ventricular ejection fraction (LVEF) of two groups after treatment was higher than that before treatment (P <0.05), and the treatment group was superior to the control group (P <0.05). Conclusion: Metoprolol sustained release tablets can improve myocardial function in patients with dilated cardiomyopathy with congestive heart failure.