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大量动物实验和流行病学调查表明,环境中亚硝酸盐浓度的升高能够导致癌症的发生。到目前为止,对于亚硝酸盐诱发癌变已经进行了大量的研究,其作用机制已经引起了广泛的关注。本文分析了外界亚硝酸盐含量的升高对体内N-亚硝基化合物和NO含量的影响,综述了N-亚硝基化合物和NO致癌的作用机制,并对亚硝酸盐引起癌变的其他机制进行了探讨。认为亚硝酸盐通过刺激体内N-亚硝基化合物和NO的生成,导致癌变的发生,同时亚硝酸盐刺激肿瘤新血管生成和亚硝酸盐作为癌变细胞糖酵解的氢受体也对癌变的发生起了重要作用。
A large number of animal experiments and epidemiological surveys have shown that elevated levels of nitrites in the environment can lead to cancer. To date, a great deal of research has been conducted on nitrite-induced carcinogenesis, and its mechanism of action has drawn wide attention. In this paper, we analyzed the effect of external nitrite content on N-nitroso compounds and NO content in vivo, reviewed the mechanism of N-nitroso compounds and NO carcinogenesis, and discussed other mechanisms of nitrite-induced carcinogenesis Discussed. Nitrite is believed to cause carcinogenesis by stimulating the production of N-nitroso compounds and NO in the body, while nitrite stimulates tumor neovascularization and nitrite as a hydrogen receptor for canceration of glycolytic cells. Occurred an important role.