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目的观察在腹腔镜的基础上联合新辅助化疗方案治疗低位直肠癌的疗效及安全性。方法低位直肠癌确诊患者120例均接受常规对症治疗和密切护理,并行腹腔镜手术联合新辅助化疗治疗。观察患者化疗前后直肠癌TNM分期变化情况,并统计不良反应。结果化疗后患者直肠癌TNM分期降低显著,与术前比较差异有统计学意义(P<0.05);不良反应包括胃肠道反应、骨髓抑制以及肝肾功能异常,其中以胃肠道反应最多见。结论新辅助化疗可显著减低癌症分期,与腹腔镜联合治疗低位直肠癌可获得良好的治疗效果,具有一定的临床应用价值。
Objective To observe the efficacy and safety of laparoscopic combined with neoadjuvant chemotherapy in the treatment of low rectal cancer. Methods 120 patients diagnosed with low rectal cancer patients underwent routine symptomatic treatment and close nursing, and concurrent laparoscopic surgery combined with neoadjuvant chemotherapy. Observed before and after chemotherapy in patients with TNM staging of rectal cancer changes, and statistical adverse reactions. Results The TNM staging of patients with rectal cancer after chemotherapy decreased significantly, compared with the preoperative difference was statistically significant (P <0.05); adverse reactions include gastrointestinal reactions, bone marrow suppression and liver and kidney dysfunction, of which the most common gastrointestinal reactions . Conclusion Neoadjuvant chemotherapy can significantly reduce the cancer staging, and laparoscopy combined treatment of low rectal cancer can obtain good therapeutic effect, has a certain clinical value.