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目的评价奥曲肽联合普萘洛尔治疗肝硬化上消化道出血的临床疗效。方法 146例肝硬化上消化道出血患者,按随机对照法分为观察组与对照组,每组73例。观察组患者给予奥曲肽联合普萘洛尔治疗,对照组患者给予单纯奥曲肽治疗。比较两组患者的临床疗效、止血时间及再出血发生率。结果观察组治疗总有效率为93.2%,明显高于对照组的79.5%,差异具有统计学意义(P<0.05)。观察组患者止血时间为(16.8±2.7)h、再出血发生率为4.1%,均优于对照组的(24.3±3.5)h、15.1%,差异具有统计学意义(P<0.05)。结论普萘洛尔与奥曲肽联合应用能进一步提高肝硬化上消化道出血患者的止血效果,降低再出血风险,应在临床实际应用过程中进一步推广。
Objective To evaluate the clinical efficacy of octreotide combined with propranolol in the treatment of upper gastrointestinal hemorrhage with cirrhosis. Methods A total of 146 patients with cirrhosis and upper gastrointestinal bleeding were randomly divided into observation group and control group with 73 cases in each group. Patients in the observation group were treated with octreotide plus propranolol, while patients in the control group were given octreotide alone. The clinical efficacy, bleeding time and the incidence of rebleeding were compared between the two groups. Results The total effective rate of observation group was 93.2%, which was significantly higher than 79.5% of control group, the difference was statistically significant (P <0.05). The bleeding time in the observation group was (16.8 ± 2.7) h and the rate of rebleeding was 4.1%, which was significantly better than that in the control group (24.3 ± 3.5) h and 15.1%, respectively. The difference was statistically significant (P <0.05). Conclusion The combination of propranolol and octreotide can further improve the hemostatic effect and reduce the risk of rebleeding in patients with cirrhosis and upper gastrointestinal hemorrhage. It should be further popularized in the clinical practice.