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615系和昆明种小鼠经含A蛋白葡萄球菌腹腔免疫后两周,分别用小鼠腹水肝癌(H_(22))、恶性淋巴瘤(ARS)及白血病(L7712)细胞(1×10~5)腹腔攻击,观察二个月。结果表明,SPA菌免疫动物对H_(22)肝癌细胞攻击的保护率为30％,抑制率为143.6％,对SRS恶性淋巴瘤细胞攻击的保护率为15％,抑制率达207.8％;对L7712白血病细胞攻击的抑制率为216.0％。SPA菌诱导的免疫保护效应强度不低子厌氧棒状杆菌免疫组。这些结果进一步证明,SPA菌腹腔免疫能诱导非特导性抗肿瘤免疫效应。
Two weeks after intraperitoneal immunization with A protein Staphylococcus in 615 and Kunming mice, mouse ascites hepatocellular carcinoma (H_(22)), malignant lymphoma (ARS) and leukemia (L7712) cells (1×10~5) were used respectively. ) Abdominal attacks were observed for two months. The results showed that the protection rate of SPA-immunized animals against H_(22) hepatoma cells was 30%, and the inhibition rate was 143.6%. The protection against SRS lymphoma cells was 15%, and the inhibition rate was 207.8%; for L7712 The inhibitory rate of leukemia cell challenge was 216.0%. The immunoprotective effect induced by SPA bacteria was not lower than that of the anaerobic corynebacterium group. These results further demonstrate that SPA bacteria immunization can induce non-specific anti-tumor immune effects.