论文部分内容阅读
镇痛药的实验方法在文献所见已经很多,主要是利用机械、热及电等三种刺激为主,但是其中除了热板法,目前比较广泛采用外,其他的方法不是由于装置或方法的复杂,就是由于指标不明确等原因而未见普遍使用。更重要的是目前许多镇痛试验方法对镇痛效能较弱的药物,如解热镇痛药尚不能测得其镇痛效果,因此有必要进一步寻求更理想的方法。 Van der Wende及Margolin曾首先用碘甲酸钠对大白鼠腹腔注射而引起一种“扭歪综合征”(Writhing Syndrome)来试验镇痛药。
Analgesic experimental methods have been seen in the literature has many, mainly the use of mechanical, thermal and electrical stimulation of the three main, but in addition to the hot plate method, the more widely used, the other method is not due to the device or method Complex, is due to indicators such as ambiguity and no reason to use. More importantly, many of the current analgesic test methods for analgesic drugs, such as antipyretics and analgesics can not be measured analgesic effect, it is necessary to further search for a more ideal method. Van der Wende and Margolin first used a sodium iodoform for intraperitoneal injection to induce a “Writhing Syndrome” to test analgesics.