自1973年Tilney提出多器官功能衰竭(multiple organ failure, MOF)这一概念后逐渐为临床所重视。其发病机理尚未完全明瞭,曾有内毒素、低血流灌注、胃肠道屏障障碍、氧化还原和再灌注等学说。根据目前多数资料表明MOF的基本病理生理过程是免疫功能异常。 1 免疫效应细胞功能异常 1.1 巨噬细胞、中性多形核白细胞被激活,在炎症部位聚集、吞噬,释放出一系列酶,包括蛋白溶解酶、弹力酶、胶原酶、纤维蛋白溶解酶激活酶、酸性水解酶等,以把炎症局限、清除病灶和抗原,保护机体,如这些细胞 Since 1973, Tilney proposed the concept of multiple organ failure (MOF) gradually became clinically important. The pathogenesis is not yet fully understood, there have been endotoxin, low blood perfusion, gastrointestinal barrier disorders, redox and reperfusion theory. According to most of the data show that the basic pathophysiology of MOF is immune dysfunction. 1 Immune effector cell dysfunction 1.1 Macrophages, neutral polymorphonuclear leukocytes are activated in the inflammatory site aggregation, phagocytosis, release a series of enzymes, including proteolytic enzyme, elastase, collagenase, fibrinolytic enzyme , Acid hydrolase, etc., in order to limit inflammation, remove lesions and antigens, protect the body, such as these cells