论文部分内容阅读
目的:探讨肥胖伴随动脉硬化发生与血清脂肪因子浓度的相关性。方法:收集肥胖伴随动脉硬化患者103例,正常血清55例,以酶联免疫分析法测定血清样本的脂联素、抵抗素、瘦素和内脏脂肪素的浓度,以单链构象多态性多聚酶链反应法检查了2组病人间4种脂肪因子的基因多态性差异。结果:肥胖伞随动脉硬化组血清脂联素、抵抗素和内脏脂肪素浓度较之对照组差异显著(P<0.05),瘦素浓度无差异。同时肥胖伴随动脉硬化组患者的瘦素基因较之对照组有4个碱基的差异。结论:脂肪因子有可能做为肥胖引起的动脉硬化的治疗依据和预测指标。
Objective: To investigate the correlation between obesity and arteriosclerosis and serum adiponectin concentration. Methods: A total of 103 obese patients with atherosclerosis and 55 normal controls were enrolled in this study. The concentrations of adiponectin, resistin, leptin and visfatin were measured by enzyme-linked immunosorbent assay (ELISA) Chain reaction method examines two groups of patients with four kinds of adipokines gene polymorphism differences. Results: Serum levels of adiponectin, resistin and visfatin in obese patients with atherosclerosis were significantly lower than those in the control group (P <0.05). There was no difference in serum leptin levels. At the same time obesity patients with atherosclerosis leptin gene compared with the control group has a 4-base difference. Conclusion: Adiponectin may be used as the treatment basis and prediction index of atherosclerosis caused by obesity.