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目的了解喘息与非喘息型病毒性肺炎患儿淋巴细胞亚群的改变。方法对2002—2004在北京友谊医院就诊的急性期喘息型病毒性肺炎患儿37例及非喘息型病毒性肺炎患儿32例,采用流式细胞仪对其外周血淋巴细胞亚群进行检测。并以30例健康儿童作为对照组。结果喘息组与非喘息组病毒性肺炎患儿急性期外周血T辅助淋巴细胞亚群Th1细胞百分率分别为(12·61±7·19)%及(17·32±9·92)%,与对照组[(9·16±9·90)%]比较差异均有显著的统计学意义(P<0·001);喘息组与非喘息组患儿Th1/Th2比值均高于对照组(P<0·05,P<0·01)。此外与非喘息组比较,喘息组CD4+/CD8+较高(P<0·05),但其他各项指标差异均无统计学意义。结论病毒性肺炎时不论是否发生喘息,均呈现Th1应答优势。喘息型病毒性肺炎患儿除CD4+/CD8+较非喘息型病毒性肺炎高外,其他各项淋巴细胞亚群差异无明显统计学意义。
Objective To investigate the changes of lymphocyte subsets in children with wheezing and non-wheezing viral pneumonia. Methods Thirty-seven children with acute asthmatic pneumonia and 32 non-asthmatic children with pneumonia were treated in Beijing Friendship Hospital from 2002 to 2004. The peripheral blood lymphocyte subsets were detected by flow cytometry. And 30 healthy children as a control group. Results The percentages of Th1 cells in peripheral blood T helper lymphocyte subsets in asthmatic children and non-asthmatic children with pneumonia were (12.61 ± 7.19)% and (17.32 ± 9.92)%, respectively, (9 · 16 ± 9 · 90)%] in the control group were significantly different (P <0.001); Th1 / Th2 ratio in the asthmatic group and non-asthmatic group was higher than that in the control group (P <0.05, P <0.01). In addition, compared with non-wheezing group, wheezing group CD4 + / CD8 + higher (P <0.05), but no significant difference in other indicators. Conclusions Viral pneumonia, regardless of wheezing, presents a Th1 response predominance. Children with wheezing pneumonia except CD4 + / CD8 + non-wheezing pneumonia than the high, the other lymphocyte subsets differences were not statistically significant.