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目的 :从神经内分泌免疫网络调节来探讨心理社会应激影响银屑病的可能中介机制。方法 :运用临床心理测定工具 (TABPQ ,TAS ,SAS ,SDS)测定 40例银屑病患者及 3 8例正常对照组在病前遭遇的人格特征、患病后的心身健康状况 ;用放射免疫分析方法分别测定 40例银屑病患者的神经肽Y (NPY)、白介素 6(IL -6)、白介素 8(IL -8)、皮质醇 (Cortisol)的含量 ,并与 3 8例健康对照组进行对照研究 ;将患者的心理社会因素与生物学指标进行Pearson相关分析。结果 :1 病例组A型行为评分、TAS总分、抑郁及焦虑分值均显著高于对照组。 2 病例组的IL -6、IL -8均显著高于对照组 (P <0 0 1) ,NPY和Cor的含量高于对照组 (P <0 0 5 )。 3 通过相关分析发现患者的抑郁焦虑分、TAS总分与IL -6、IL -8、NPY、Cortisol有显著正相关性 ,TH +CH分与NPY、IL -6有显著正相关性 ,TH +CH分与IL -8、Cor没有显著相关性。结论 :心理社会指标与银屑病患者的某些神经内分泌免疫指标有相关性
OBJECTIVE: To explore the possible mechanism of psychosocial stress affecting psoriasis from neuroendocrine immune network. Methods: The personality traits of 40 psoriasis patients and 38 healthy controls before and after illness were measured by clinical psychometric tools (TABPQ, TAS, SAS, SDS) Methods The levels of neuropeptide Y (NPY), interleukin 6 (IL -6), interleukin 8 (IL -8) and cortisol in 40 patients with psoriasis were measured and compared with 38 healthy controls Control study; Pearson correlation analysis was used to analyze the patients’ psychosocial factors and biological indexes. Results: 1 case group A type behavior score, TAS score, depression and anxiety scores were significantly higher than the control group. IL-6 and IL-8 in 2 cases were significantly higher than those in control group (P <0.01). The contents of NPY and Cor were higher than those in control group (P <0.05). There was a significant positive correlation between TAS score and IL-6, IL-8, NPY and Cortisol. Correlation analysis showed that there was a significant positive correlation between TH + CH score and NPY, IL-6 and TH + CH points and IL -8, Cor no significant correlation. CONCLUSIONS: There is a correlation between psychosocial indicators and some neuroendocrine immune parameters in patients with psoriasis