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本文观察了63例肾脏疾病患儿末梢血中性粗细胞(PMN)产生活性氧(ROS)能力。结果发现在急性期或肾病期,急性肾袁、慢性肾衰患儿PMN自发性合成ROS增多,急性肾炎、肾病或紫癜性肾炎合成ROS也增多;而激发后ROS产生在肾病、紫癜性肾炎或慢性肾衰患儿明显下降,在急性肾炎或急性肾衰无明显变化。进入缓解期或恢复期,各组病儿PMN自发性或激发后ROS合成均正常。本研究提示患肾脏疾病时中性粒细胞合成ROS异常。
In this paper, 63 patients with renal disease peripheral blood mononuclear cells (PMN) to produce reactive oxygen species (ROS). The results showed that acute or nephropathy, acute kidney disease, chronic renal failure in children with spontaneous synthesis of PMN increased ROS, acute nephritis, nephropathy or purpura nephritis synthesis of ROS also increased; while the excitation of ROS in nephropathy, purpura nephritis or Children with chronic renal failure decreased significantly, no significant changes in acute nephritis or acute renal failure. Into the remission or recovery period, PMN spontaneous or excited after each group of ROS synthesis were normal. This study suggests that nephropathy synthesizes ROS abnormalities when suffering from kidney disease.