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目的:探讨二甲双胍联合美托洛尔治疗糖尿病合并高血压疗效。方法:将60例2型糖尿病合并高血压患者按照1:1的比例随机地均分为对照组与观察组,对照组仅采用二甲双胍进行治疗,观察组在此基础上联合美托洛尔治疗。比较两组治疗前后血压(收缩压及舒张压)及空腹血糖水平变化情况、不良反应发生情况。结果:(1)两组治疗后收缩压、舒张压及空腹血糖水平均显著低于治疗前,差异也均具有统计学意义(P<0.05);(2)两组治疗过程中的不良反应发生率差异无统计学意义(P>0.05)。结论:二甲双胍联合美托洛尔治疗糖尿病合并高血压疗效显著,安全性较高,应加以推广及应用。
Objective: To investigate the efficacy of metformin combined with metoprolol in the treatment of diabetic patients with hypertension. Methods: Sixty patients with type 2 diabetes mellitus complicated with hypertension were randomly divided into control group and observation group according to the ratio of 1: 1. The control group was treated with metformin alone. The observation group was treated with metoprolol on the basis of this. The changes of blood pressure (systolic and diastolic blood pressure) and fasting blood glucose level before and after treatment were compared between the two groups. The incidence of adverse reactions was compared. Results: (1) The systolic blood pressure, diastolic blood pressure and fasting blood glucose of the two groups were significantly lower than those before treatment (P <0.05); (2) Adverse reactions occurred in the two groups The difference was not statistically significant (P> 0.05). Conclusion: Metformin combined with metoprolol has significant therapeutic effect on diabetes mellitus with hypertension, and should be popularized and applied.