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目的 :研究莫西沙星在感染家兔模型中的药物动力学。方法 :8只家兔经埴入高尔夫练习球并用肺炎链球菌感染 3d后 ,用多剂量口服莫西沙星治疗 ,第 5天进行药动学试验。用高效液相色谱法测定血药浓度。结果 :莫西沙星在家兔体内属线性药物并符合二房室模型 ;达峰时间为 (1.2± 0 .6)h ,峰浓度为 (13 .2± 4 .0 ) μg·ml-1,曲线下面积为 (86.5± 2 1.1) μg·ml-1·h ,消除半衰期为 (13 .0± 6.2 )h。 4只家兔高尔夫练习球内的莫西沙星血清峰浓度 ,在为 3 .6± 2 .1μg·ml-12 4h内的平均曲线下面积为 (65 .4± 2 1.1) μg·ml-1·h。结论 :获得的莫西沙星在家兔模型中的药动学参数 ,对今后莫西沙星的药效学研究有很大的帮助。
Objective: To study the pharmacokinetics of moxifloxacin in a rabbit model of infection. Methods: Eight rabbits were infused with golf practice balls and infected with Streptococcus pneumoniae for three days. Mice were treated with moxifloxacin in multiple doses and pharmacokinetic tests were performed on the fifth day. Determination of plasma concentration by high performance liquid chromatography. Results: Moxifloxacin was a linear drug in rabbits and was consistent with two-compartment model. The peak time was (1.2 ± 0.6) h and the peak concentration was (13.2 ± 4. 0) μg · ml-1. The curve Under the area of (86.5 ± 2 1.1) μg · ml-1 · h, the elimination half-life was (13.0 ± 6.2) h. The serum peak concentrations of moxifloxacin in four rabbit golf practice balls were (65.4 ± 2.1.1) μg · ml-1 at an average curve within 3.6 ± 2.1 microg / ml for 12 h H Conclusion: The obtained pharmacokinetic parameters of moxifloxacin in a rabbit model are of great help to the future pharmacodynamic study of moxifloxacin.