肝素是由硫酸化D-葡萄糖胺、D-葡萄糖醛酸和L-艾杜糖醛酸所构成的聚合物,分子量差异很大,商品肝素的分子量从5千到3万。因种类的不同,肝素在结构上和抗凝特性上也不相同。肝素能与抗凝血酶Ⅲ(ATⅢ)的赖氨酸残基相结合,使ATⅢ的构形发生变化,促进凝血酶等对ATⅢ活性部位的结合,因而呈现其抗凝特性。现已知支配肝素与ATⅢ相结合 Heparin is a polymer of sulfated D-glucosamine, D-glucuronic acid and L-iduronic acid, with a wide range of molecular weights, ranging in molecular weight from 5,000 to 30,000. Due to the different types of heparin in the structure and anticoagulant properties are not the same. Heparin can combine with the lysine residues of antithrombin Ⅲ (AT Ⅲ) to change the configuration of AT Ⅲ and promote the binding of thrombin and other active sites to AT Ⅲ, thus exhibiting anticoagulant properties. Now known to dominate the combination of heparin and AT Ⅲ