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为探讨白介素-2受体(IL-2R,即CD25)在同种异体肾移植急性细胞性排异(ACR)临床诊断的作用,着重观察移植肾发生(ACR)和无ACR时,其间质浸润细胞中IL-2R阳性细胞数的变化,及其与间质浸润的淋巴细胞的关系。作者选择同期行异体肾移植,且无并发症患者17例,采用PAP四层免疫酶标法,检测移植肾组织中间质浸润细胞中IL-2R阳性细胞数的变化。结果显示:无ACR的肾组织中,IL-2R阳性细胞仅轻度增加,当移植肾出现ACR时,IL-2R阳性细胞数的增加十分显著,并与间质浸润的CD8密切相关。作者认为IL-2R对于ACR的诊断及鉴别诊断具有一定的临床应用价值。
To investigate the role of interleukin-2 receptor (CD25) in the clinical diagnosis of acute renal cell rejection (ACR) in allogeneic kidney transplantation, the effects of interleukin-2 receptor (ACR) The number of IL-2R-positive cells in infiltrating cells and their relationship with interstitial infiltrating lymphocytes. The authors chose 17 cases of allogeneic kidney transplantation and no complications in the same period, using PAP four-layer immunoenzyme method to detect the number of IL-2R-positive cells in the interstitial infiltrating cells in renal allograft. The results showed that IL-2R-positive cells increased only mildly in ACR-free kidneys. When ACR was detected in renal allografts, the number of IL-2R positive cells was significantly increased and closely related to interstitial infiltration of CD8. The authors believe that IL-2R for the diagnosis and differential diagnosis of ACR has some clinical value.