供氧可改善伴有运动性低氧血症的慢性阻塞性肺疾病(COPD)的运动功能和呼吸困难,但由于缺乏严格匹配对照研究,结论有争议。本文就此类患者肺康复期间供氧的意义进行了随机、对照的研究。 6周内无急性恶化的稳定期COPD患者25例,一秒用力呼气量(FEV1)<40％预计值,吸入羟甲叔丁肾上腺素400μg后可逆部分<15％。均伴有运动性呼吸困难,运动期间动脉血氧饱和度较基础值下降≥4％并≤90％。其中接受家庭长期氧疗11例。 运动功能测定采用往返式步行试验(SWT),每例测定3次,各次之间至少休息20min。基础步行测试在吸入空气条件下进行,后2次测试经鼻导管随机吸入重量为2.5kg的便携式瓶装压缩空气或 Oxygen supply improves motor function and dyspnea in chronic obstructive pulmonary disease (COPD) with exercise-induced hypoxemia, but the conclusions are controversial due to the lack of a rigorously matched control study. This article conducted a randomized, controlled study of the significance of oxygenation during pulmonary rehabilitation in such patients. Twenty-five patients with stable COPD without acute exacerbations within 6 weeks, predicted FEV 1 <40%, and reversible fractions <15% after 400 μg MEBO were inhaled. Are associated with exercise-induced dyspnea, arterial oxygen saturation during exercise than the basic value of ≥ 4% and ≤ 90%. Among them, 11 cases received long-term oxygen therapy. Motor function test using round-trip walk test (SWT), each measured 3 times, between rest at least 20min. The basic walk test was performed under inhalation air, followed by two tests of nasal cannula random inhalation of 2.5 kg of portable compressed air bottle or