为了进一步阐明烧伤后糖皮质激素受体(GR)减少的意义,本实验以GR的竞争性拮抗剂RU38486阻断烧伤大鼠体内的GR,并通过检测预先注射了异硫氰酸荧光素钠标记牛血浆白蛋白(简称荧光蛋白)的大鼠的肺、肾组织匀浆中荧光蛋白的含量,观察了GR对严重烫伤大鼠肺、肾血管壁通透性的影响。结果表明:严重烧伤后12h,大鼠肺、肾组织匀浆中荧光蛋白的含量分别为6.34±0.34和15.11±3.20μg/g组织,明显高于对照组的5.82±0.26和 In order to further clarify the significance of glucocorticoid receptor (GR) reduction after burn, we used the RU38486, a competitive antagonist of GR, to block the GR in burned rats and detected the expression of sodium fluorescein isothiocyanate The content of fluorescent protein in the lung and kidney homogenate of bovine plasma albumin (abbreviated as fluorescent protein) rats was observed. The effect of GR on the permeability of vascular wall in the lung and renal of severe scalded rats was observed. The results showed that the content of fluorescent protein in rat lung and kidney homogenate were 6.34 ± 0.34 and 15.11 ± 3.20μg / g respectively at 12h after severe burn, which was significantly higher than that of control group (5.82 ± 0.26 and