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目的探讨急性脑梗死患者血浆纤溶酶原激活物抑制物(PAI)、D-二聚体、血栓调节蛋白(TM)变化与中医痰证、血瘀证变化的关系。方法观察122例急性脑梗死患者,于入院第1天及第14天测定患者血浆PAI、D-二聚体、TM的含量,并记录中医痰证、血瘀证积分,对化验指标的前后差值及证候积分的前后差值进行线性回归分析。结果PAI变化与痰证积分变化存在线性回归关系(P=0.011),D-二聚体变化与血瘀证积分变化存在线性回归关系(P=0.038),TM变化与血瘀证积分变化存在线性回归关系(P=0.034)。结论PAI、D-二聚体、TM与痰证、血瘀证有相关性,中医痰证、血瘀证的证候变化能在一定程度上体现急性脑梗死患者体内凝血-纤溶失衡时凝血纤溶功能的动态变化。
Objective To investigate the relationship between changes of plasma plasminogen activator inhibitor (PAI), D-dimer and thrombomodulin (TM) in patients with acute cerebral infarction and changes of TCM phlegm and blood stasis syndrome. Methods The plasma levels of PAI, D-dimer and TM were measured in 122 patients with acute cerebral infarction on the first day and the 14th day after admission. The phlegm syndromes and blood stasis syndrome scores of TCM were recorded. Linear regression analysis of the value before and after the difference between the card points and syndromes. Results There was a linear regression relationship between change of PAI and score of phlegm syndrome (P = 0.011). There was a linear regression relationship between changes of D-dimer and score of blood stasis syndrome (P = 0.038) Regression relationship (P = 0.034). Conclusion PAI, D-dimer, TM and phlegm syndrome and blood stasis syndrome are correlated. The syndrome changes of TCM phlegm syndrome and blood stasis syndrome can reflect the coagulation-fibrinolytic coagulation in patients with acute cerebral infarction to a certain extent Dynamic changes in fibrinolytic function.