Milbemycin D(MMD)系大环内脂化合物,其结构类似伊维菌素(ivermectin)。本文报道MMD在棉鼠体内外杀灭棉鼠丝虫微丝蚴的效果。体内试验按Petranyi和Mieth法用20条棉鼠丝虫感染期幼虫经胸腔感染棉鼠。感染10周后,从鼠尾静脉取血检查,微丝蚴阳性者用作实验,每组4或5只棉鼠。(1)皮下注射:将MMD溶于含2%Cremophor EL的生理盐水。每组的剂量分别为0.5、5和50mg/kg,连续5天。给药30分钟后,各组 Milbemycin D (MMD) is a macrolide compound with a structure similar to ivermectin. This article reports the efficacy of MMD in killing cotton wool microfilariae in mice and in vivo. In Vivo In Vivo Experiments Cotton buds were infected thoracotomy with 20 cotton ticks in the Petranyi and Mieth method. After 10 weeks of infection, blood was taken from the tail vein of the rat and tested for positive microfilariae, 4 or 5 cotton rats per group. (1) Subcutaneous injection: The MMD is dissolved in physiological saline containing 2% Cremophor EL. The doses for each group were 0.5, 5 and 50 mg / kg, respectively, for 5 consecutive days. After administration for 30 minutes, each group