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目的:观察乌司他丁与激素对肺挫伤的治疗作用。方法:将36例肺挫伤病例随机分为3组:A组:常规治疗加甲强龙6d;B组:常规治疗加乌司他丁6d;C组:常规治疗加甲强龙6d加乌司他丁6d。分别测定3组患者在治疗前(d0)、治疗第4天(d4)、治疗第7天(d7)的呼吸频率、二氧化碳分压(PaCO2)、氧合指数、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的数值,并进行相互比较。结果:3组病例在治疗前(d0)的呼吸频率、PaCO2、氧合指数、TNF-α、IL-6无显著差异;治疗前后呼吸频率、PaCO2、氧合指数在各组中d0与d4相比,d0与d7相比,均可见显著性差异。治疗前后,TNF-α、IL-6在各组中d0与d4相比,d0与d7,d4与d7相比差异均有统计学意义。结论:乌司他丁、激素能抑制炎症介质,对肺挫伤有治疗效果。乌司他丁加激素的疗效与单用激素、单用乌司他丁的疗效差异无统计学意义。
Objective: To observe the therapeutic effect of ulinastatin and hormones on pulmonary contusion. Methods: Thirty-six cases of pulmonary contusion were randomly divided into three groups: group A: conventional treatment plus methylprednisolone for 6 days; group B: routine treatment plus ulinastatin for 6 days; group C: conventional treatment plus methylprednisolone He Ding 6d. The respiratory rate, PaCO2, oxygenation index, tumor necrosis factor-α (TNF-α) in the three groups before treatment (d0), on the fourth day of treatment (d4), on the seventh day of treatment (d7) α), interleukin-6 (IL-6), and compared with each other. Results: There were no significant differences in respiratory rate, PaCO2, oxygenation index, TNF-α and IL-6 between the three groups before and after treatment. Before and after treatment, respiratory rate, PaCO2 and oxygenation index were higher in d0 and d4 Compared to d0 and d7, significant differences were observed. Before and after treatment, TNF-α and IL-6 in each group d0 compared with d4, d0 and d7, d4 compared with d7 were statistically significant. Conclusion: Ulinastatin, a hormone that inhibits inflammatory mediators, has a therapeutic effect on pulmonary contusion. Ulinastatin plus hormones and hormone alone, the effect of ulinastatin alone was not statistically significant.