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目的:制备高乌甲素固体分散体,提高其溶解度及溶出速率。方法:以PVP-K30为载体,溶剂法制备固体分散体,通过X射线衍射法(XRD)、差示量热扫描法(DSC)对其进行表征,研究高乌甲素在固体分散体中的存在状态,并对其体外溶出度进行测定。结果:高乌甲素制备成固体分散体后,以无定型状态高度分散在PVP-K30载体材料中,溶解度及溶出速率得到明显提高。结论:将高乌甲素制备成固体分散体后,可显著提高其溶解度、累积溶出度及溶出速率,为进一步制剂革新提供了实验依据。
Objective: To prepare lappaconitine solid dispersion to improve its solubility and dissolution rate. Methods: PVP-K30 was used as solvent to prepare solid dispersions by solvent method. The solid dispersions were characterized by X-ray diffraction (XRD) and differential scanning calorimetry (DSC) Presence, and its in vitro dissolution was determined. Results: After the lappaconitine was prepared into a solid dispersion, it was highly dispersed in the PVP-K30 carrier material in an amorphous state, and the solubility and dissolution rate were significantly improved. CONCLUSION: The preparation of solid dispersions of lappaconitine can significantly improve the solubility, cumulative dissolution rate and dissolution rate of lappaconitine and provide an experimental basis for further formulation innovation.