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目的研究比较党参超微粉与普通粉对胃溃疡大鼠胃黏膜损伤的保护作用。方法制备乙酸致胃黏膜损伤型大鼠胃溃疡模型,经2种粉末治疗10 d后,测定溃疡面积,计算溃疡指数;分别用放射免疫法检测各组大鼠血清中胃泌素(gastrin,Gas)及血浆中6-keto-PGF1α含量,并采用酶联免疫法测定血清中表皮生长因子(EGF)含量。结果 2组大鼠溃疡指数均低于模型组,且超微粉组明显低于普通粉组;超微粉组大鼠血清Gas含量低于普通粉组,6-keto-PGF1α和EGF含量高于普通粉组。结论党参超微粉对胃溃疡的疗效优于普通粉,超微粉碎有助于提高党参药效。
Objective To study the protective effects of Codonopsis powder and common powder on gastric mucosal lesion in gastric ulcer rats. Methods Gastric ulcer induced by acetic acid in rats with gastric mucosal lesion was prepared. After treated with 2 kinds of powder for 10 days, the area of ulcer was determined and the ulcer index was calculated. The levels of gastrin (Gastrin, ) And plasma 6-keto-PGF1α levels, and serum epidermal growth factor (EGF) levels by enzyme-linked immunosorbent assay. Results The ulcer index of the two groups were lower than the model group, and the ultrafine powder group was significantly lower than the normal powder group; the serum gas content of the ultrafine powder group was lower than the normal powder group, the content of 6-keto-PGF1α and EGF was higher than the normal powder group. Conclusion The effect of Codonopsis ultrafine powder on gastric ulcer is better than that of common powder, which can help improve the effect of Codonopsis.