论文部分内容阅读
目的:探讨补肾药复方左归胶囊对于药物流产大鼠子宫内膜的修复作用,为临床用药提供实验依据。方法:采用妊娠大鼠灌服米非司酮和米索前列醇造成完全流产模型48例,随机分为空白组、西药组、祛瘀组、补肾组,于流产次日开始分别灌胃相应药物5天,用药结束后观察各组药物流产大鼠血清雌二醇(E_2)、孕酮(P)及子宫内膜组织内皮生长因子(VEGF)的变化。结果:与空白组比较,祛瘀组和补肾组VEGF和E_2的表达明显升高,西药组E_2含量明显升高,补肾组P含量明显降低,差异均有统计学意义(P<0.05,P<0.01);与西药组比较,祛瘀组和补肾组VEGF的表达明显升高,补肾组P含量降低更明显,差异均有统计学意义(P<0.05,P<0.01);与祛瘀组比较,补肾组E_2含量升高的更明显,差异有统计学意义(P<0.01)。结论:补肾药复方左归胶囊可提高药流大鼠雌激素水平,降低孕激素水平,提高子宫内膜组织VEGF含量,达到促进子宫内膜修复的作用。
Objective: To investigate the effect of Zuogui Capsule, a traditional Chinese medicine for kidney-tonifying, on the repair of endometrium in medical abortion rats and provide experimental evidence for clinical use. Methods: Forty-eight cases of complete abortion model induced by mifepristone and misoprostol in pregnant rats were randomly divided into blank group, western medicine group, stasis removing group and kidney tonifying group. The rats were given the corresponding drugs After 5 days, the changes of serum estradiol (E2), progesterone (P) and endometrial tissue endothelial growth factor (VEGF) levels were observed in each group. Results: Compared with the blank group, the expression of VEGF and E_2 in the Quyu group and the Bushen group were significantly increased, while the content of E_2 in the Western medicine group was significantly increased (P <0.05, P < 0.01). Compared with Western medicine group, the expression of VEGF in Qu-stasis group and Bushen group were significantly increased, while the P-content in Bushen group was more obvious, the differences were statistically significant (P <0.05, P <0.01) , While the content of E 2 in kidney invigorating group was more obvious, the difference was statistically significant (P <0.01). Conclusion: Zuogui capsule can increase estrogen level, reduce the level of progesterone, increase the content of VEGF in endometrial tissue and promote endometrial repair.